Symbol
Name
ID

Bcl3
B cell leukemia/lymphoma 3
MGI:88140

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

decreased B cell apoptosis

decreased B cell proliferation

increased B cell proliferation

enlarged spleen

increased spleen weight

abnormal B cell differentiation

abnormal class switch recombination

decreased immature B cell number

decreased transitional stage T1 B cell number

decreased transitional stage T2 B cell number

abnormal transitional stage T3 B cell morphology

abnormal dendritic cell number

increased plasmacytoid dendritic cell number

decreased B-1 B cell number

decreased B-1a cell number

decreased B-1b cell number

decreased follicular B cell number

decreased marginal zone B cell number

absent marginal zone B cells

increased B-1 B cell number

increased marginal zone B cell number

decreased B cell number

increased central memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

decreased central memory CD8 positive, alpha-beta T cell number

increased CD8-positive, alpha-beta memory T cell number

increased CD8-positive, alpha-beta T cell number

increased lymphocyte cell number

decreased macrophage cell number

increased macrophage cell number

abnormal myeloid dendritic cell morphology

abnormal lymphocyte morphology

abnormal B-2 B cell morphology

abnormal follicular B cell morphology

abnormal metallophilic macrophage morphology

abnormal spleen marginal zone macrophage morphology

intermingled spleen red and white pulp

absent spleen germinal center

decreased spleen germinal center size

disorganized spleen B cell follicle

abnormal B cell physiology

decreased IgD level

decreased IgE level

decreased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG3 level

decreased IgG level

decreased IgM level

increased IgM level

abnormal cytotoxic T cell physiology

abnormal macrophage physiology

abnormal follicular dendritic cell morphology

abnormal Peyer's patch morphology

abnormal Peyer's patch follicle morphology

abnormal Peyer's patch T cell area morphology

abnormal Peyer's patch germinal center morphology

decreased Peyer's patch number

small Peyer's patches

abnormal lymph node B cell domain morphology

lymph node hypoplasia

abnormal humoral immune response

abnormal cytokine secretion

decreased interferon-gamma secretion

decreased interleukin-12 secretion

abnormal innate immunity

increased susceptibility to bacterial infection

increased susceptibility to parasitic infection

Availability

Mouse Genotype

Bcl3^m1Btlr/Bcl3^m1Btlr

Bcl3^m2Btlr/Bcl3^m2Btlr

Bcl3^m3Btlr/Bcl3^m3Btlr

Bcl3^{tm1b(EUCOMM)Wtsi}/Bcl3^{tm1b(EUCOMM)Wtsi}

Bcl3^tm1Rie/Bcl3^tm1Rie

Bcl3^tm1Rsch/Bcl3^tm1Rsch

Bcl3^tm1Sbn/Bcl3^tm1Sbn

Bcl3^tm1Ver/Bcl3^tm1Ver

Bcl3^m1Btlr/Bcl3⁺

Gt(ROSA)26Sor^{tm1(CAG-Bcl3,-EGFP)Hoev}/Gt(ROSA)26Sor⁺
Cd19^tm1(cre)Cgn/Cd19⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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